OPTUNE is a wearable, portable US FDA-approved treatment1

US FDA = United States Food and Drug Administration

OPTUNE is a wearable, portable US FDA-approved treatment1

US FDA = United States Food and Drug Administration

I hope that I can travel, have fun, and create more happy memories with my family in the future.2
Denis
OPTUNE User

I hope that I can travel, have fun, and create more happy memories with my family in the future.2
Denis
OPTUNE User

About OPTUNE

OPTUNE delivers alternating electric fields without increasing chemotherapy-related side effects. Electric fields are tuned to specific frequencies that disrupt cells’ ability to multiply.1

OPTUNE requires no regular maintenance. It should be used for as many hours as possible per day, and can be carried around with you in a bag for use in your daily life.1

OPTUNE is a prescription medical device approved in US and Europe. Please contact your physician for more information.1,3

I still have hope for the future. I will face my illness with a peaceful mindset. I will go traveling whenever I can.2

Mr. Wong
OPTUNE User

I still have hope for the future. I will face my illness with a peaceful mindset. I will go traveling whenever I can.2

Mr. Wong
OPTUNE User

I hope that I can travel, have fun, and create more happy memories with my family in the future.2
Denis
OPTUNE User

I still have hope for the future. I will face my illness with a peaceful mindset. I will go traveling whenever I can.2

Mr. Wong
OPTUNE User

About OPTUNE

OPTUNE delivers alternating electric fields without increasing chemotherapy-related side effects. Electric fields are tuned to specific frequencies that disrupt cells’ ability to multiply.1

OPTUNE requires no regular maintenance. It should be used for as many hours as possible per day, and can be carried around with you in a bag for use in your daily life.1

OPTUNE is a prescription medical device approved in US and Europe. Please contact your physician for more information.1,3

About OPTUNE

OPTUNE is the alternating electric fields delivery system1

About OPTUNE

OPTUNE is the alternating electric fields delivery system1

What is OPTUNE ?

OPTUNE generates low-intensity, intermediate frequency, alternating electric fields. These electric fields are delivered to the brain through transducer arrays that are placed on the scalp.4

OPTUNE is comprised of two main components, an electric field generator, and transducer arrays.4

The OPTUNE system

OPTUNE does not need regular maintenance or have any settings for you to change.
You should use OPTUNE for as many hours per day as possible, and only take short breaks for personal needs.4

How does OPTUNE work?

The alternating electric fields generated by OPTUNE are tuned to a particular frequency, specific to the cell type being treated. With OPTUNE, alternating electric fields are generated at 200kHz.4

The alternating electric fields will interfere with the way a cell divides, thereby slowing or stopping cell division and leading to death of the cell.5

Currently, the alternating electric fields have not been shown to have any effect on cells that are not undergoing division. As normal brain cells in adults divide and multiply very slowly, they are hypothesized to be little affected by the alternating electric fields.5

How does OPTUNE work?

The alternating electric fields generated by OPTUNE are tuned to a particular frequency, specific to the cell type being treated. With OPTUNE, alternating electric fields are generated at 200kHz.4

The alternating electric fields will interfere with the way a cell divides, thereby slowing or stopping cell division and leading to death of the cell.5

Currently, the alternating electric fields have not been shown to have any effect on cells that are not undergoing division. As normal brain cells in adults divide and multiply very slowly, they are hypothesized to be little affected by the alternating electric fields.5

Instructions For Use

  • Starting treatment

    You should start treatment at your doctor’s clinic. Your doctor and device support specialist from Zai Lab will teach you how to use the device, replace transducer arrays, recharge and replace batteries, and plug in the device.4

  • Using transducer arrays

    4 transducer arrays should be used at one time – 2 with a white connection end, and 2 with black connection ends. This must be done every time you change your arrays.4

    • Black arrays are placed on the front and back of your head
    • White arrays are placed on the sides of your head

  • Using transducer arrays

    Hair growth will prevent good contact between the transducer arrays and your scalp, so your scalp should be shaved each time before you apply a new set of transducer arrays.4

  • Using transducer arrays

    The transducer arrays are for single use. Used transducer arrays can be disposed in your household trash. Change transducer arrays at least 2 times per week – every 4 days at most.4

  • Connecting the transducer arrays to the device

    Connect each of the 4 transducer array connectors with black and white connection ends to the matching sockets on the connection cable. Press firmly to be sure the connectors are in all the way.4

  • Connecting and disconnecting the portable battery

    4 rechargeable batteries are included with the OPTUNE Treatment Kit. The batteries slide into the device and should be inserted until you hear a ‘click’ indicating the battery is in place.4

  • Connecting and disconnecting the portable battery

    • When connecting, gently press down to lock the battery in place. Make sure the battery latch is fully engaged.4
    • When disconnecting, press both blue buttons on the side of the battery and lift up, then remove the battery from the slot.4

  • OPTUNE uses 1 battery at a time, and each battery lasts 2-3 hours

    Replace the battery each time it runs out, and if you plan to be away from home for more than 2 hours, carry extra batteries or a power supply.4

    More information can be found in the OPTUNE User Manual.

  • Using and carrying OPTUNE

    You should keep OPTUNE on as much as possible, when awake and when sleeping.​4

    Both the electric field generator and the battery fit in a carrying bag.4

    Do not place the device in a different bag, as OPTUNE® has a fan on the inside that needs air flow.4

Patient Assistance Program

Founded by experienced pharmacists in 2007, the Hong Kong Pharmaceutical Care Foundation is a registered non-profit charitable organization.

It approves applications for the OPTUNE patient assistance program, which helps patients in need and allays their worries by providing financial support.

Applicants must be a holder of a Hong Kong identification card and have a prescription issued by the doctor. For more information about requirements, please contact the foundation.

Application Method

Please contact Hong Kong Pharmaceutical Care Foundation for details.

2979 0380 (enquiry and booking) Monday-Friday: 11:00-13:00; 14:00-17:00
Room 1, Unit 703-704, CRE Centre, 889 Cheung Sha Wan Road, Lai Chi Kok, Kowloon
http://www.pcfhk.org/en/ info@pcvghk.org 3708 8553

Upon a successful application

The Hong Kong Pharmaceutical Care Foundation will contact the eligible applicants and OPTUNE support team.
The OPTUNE support team will follow up on the patient assistance program.

Patient Assistance Program

Founded by experienced pharmacists in 2007, the Hong Kong Pharmaceutical Care Foundation is a registered non-profit charitable organization.

It approves applications for the OPTUNE patient assistance program, which helps patients in need and allays their worries by providing financial support.

Applicants must be a holder of a Hong Kong identification card and have a prescription issued by the doctor. For more information about requirements, please contact the foundation.

Application Method

Please contact Hong Kong Pharmaceutical Care Foundation for details.

2979 0380 (enquiry and booking)

Monday-Friday: 11:00-13:00; 14:00-17:00

Room 1, Unit 703-704, CRE Centre, 889 Cheung Sha Wan Road, Lai Chi Kok, Kowloon

http://www.pcfhk.org/en/

info@pcvghk.org

3708 8553

Upon a successful application

The Hong Kong Pharmaceutical Care Foundation will contact the eligible applicants and OPTUNE support team. The OPTUNE support team will follow up on the patient assistance program.

Resources / Support

If you feel any change in your health or any side effects from the treatment, call your doctor immediately.
For technical support, email infohk@zailaboratory.com
Email technical support for help with operation of the system, troubleshooting alarms, or to get replacement parts or transducer arrays.

Resources / Support

If you feel any change in your health or any side effects from the treatment, call your doctor immediately.

For technical support, email hkmedinfo@zailaboratory.com
Email technical support for help with operation of the system, troubleshooting alarms, or to get replacement parts or transducer arrays.

Contact Us

Zai Lab (Hong Kong) Limited

Room 2301, 23/F. Island Place Tower, 510 King’s Road, North Point, Hong Kong

(852) 3844 8100

(852) 3844 8188

http://www.zailaboratory.com

General enquiry: infohk@zailaboratory.com

In case of any adverse events, please contact Zai Lab (Hong Kong) Limited with the details by phone (852) 3844 8100 or email infohk@zailaboratory.com

Room 2301, 23/F, Island Place Tower, 510 King’s Road, North Point, Hong Kong
(852) 3844 8100
(852) 3844 8188
http://www.zailaboratory.com
General enquiry:
infohk@zailaboratory.com
In case of any adverse events, please contact Zai Lab (Hong Kong) Limited with the details by
phone (852) 3844 8100 or
email infohk@zailaboratory.com

References: 1. Novocure. Optune Fact Sheet. (Accessed May 2019, at https://www.novocure.com/wp-content/uploads/2016/08/OPT-539_Optune-Fact-Sheet_062016-3.pdf). 2. Zai Lab. Patient interview, dated May 10, 2021. Data on file. 3. Novocure. Novocure Announces CE Mark and First Patient Use of Second Generation Optune System. (Accessed 23rd August 2019, at https://www.novocure.com/novocure-announces-ce-mark-and-first-patient-use-of-second-generation-optune-system/). 4. Commercial Optune UM Version 02.1, Document number QSD-EUUM-002 EN(HK), Release date: Dec 2020. 5. Kirson ED, et al. Disruption of cancer cell replication by alternating electric fields. Cancer Res. 2004 May 1;64(9):3288-95.

Patient images reflect the health status of the patients at the time the photo was taken.

HK-OPT-202106-01

References

1. Novocure. Optune Fact Sheet. (Accessed May 2019, at https://www.novocure.com/wp-content/uploads/2016/08/OPT-539_Optune-Fact-Sheet_062016-3.pdf). 2. Zai Lab. Patient interview, dated May 10, 2021. Data on file. 3. Novocure. Novocure Announces CE Mark and First Patient Use of Second Generation Optune System. (Accessed 23rd August 2019, at https://www.novocure.com/novocure-announces-ce-mark-and-first-patient-use-of-second-generation-optune-system/). 4. Commercial Optune UM Version 02.1, Document number QSD-EUUM-002 EN(HK), Release date: Dec 2020. 5. Kirson ED, et al. Disruption of cancer cell replication by alternating electric fields. Cancer Res. 2004 May 1;64(9):3288-95.

Zai Lab is the authorized licensee of Novocure. Graphs and Data used with permission by Novocure.
Zai Lab (Hong Kong) Limited
Room 2301, 23/F. Island Place Tower, 510 King’s Road, North Point, Hong Kong
www.zailaboratory.com